The development of ISO 9000 certification and the future of quality management: A survey of certified firms in Hong Kong

Reports the findings of a survey on ISO 9000 certified firms in Hong Kong conducted by the University Industrial Centre of the University of Hong Kong in August 1996. Findings suggest that while in general the number of firms certified to ISO 9000 had been increasing, the proportion of small and medium firms appeared to be quite stable. Most of the small and medium firms in both manufacturing and service sectors, and a large proportion of firms in construction sectors were certified in order to satisfy the customers’ demand. Certified firms achieved certain benefits in terms of relationship with existing customers, attracting new customers and internal operations management. The findings indicated that the certified firms need to improve their relations with their subcontractors. Total quality management (TQM) was widely adopted by the firms after they were certified. A good proportion of firms sought to implement ISO 14000.published_or_final_versio

Deep lithospheric dynamics beneath the Sierra Nevada during the Mesozoic and Cenozoic as inferred from xenolith petrology

Peridotite xenoliths erupted in late Miocene basalts (~8 Ma) in the central Sierra Nevada sample a lithosphere that is vertically stratified in terms of age and thermal history. The deeper portions (~45-100 km) have asthenospheric osmium isotopic compositons and possess textural and chemical evidence for cooling from >1100° to 700-820°C. The shallower portions (<60 km) have unradiogenic Os isotopic compositions, which yield Proterozoic model ages, and contain orthopyroxenes that record temperatures as low as 670°C in their cores and heating up to 900°C on their rims. These observations suggest that the deeper xenoliths represent fragments of hot asthenosphere that upwelled to intrude and/or underplate the overlying Proterozoic lithosphere represented by the shallower xenoliths. The contrasting thermal histories between the shallow and deep xenoliths suggest that hot asthenosphere and cold lithosphere were suddenly juxtaposed, a feature consistent with the aftermath of rapid lithospheric removal or sudden intrusion of asthenospheric mantle into the lithosphere rather than passive extension. On the basis of regional tectonics and various time constraints, it is possible that this lithospheric removal event was associated with the generation of the Sierra Nevada granitic batholith during Mesozoic subduction of the Farallon plate beneath North America. Pleistocene basalt-hosted xenoliths record a different chapter in the geodynamic history of the Sierras. These xenoliths are relatively fertile, come from depths shallower than 45-60 km, are characterized by asthenospheric Os isotopic compositions, record hot equilibration temperatures (1000°-1100°C), and show no evidence for cooling. The strong contrast in composition and thermal history between the Pleistocene and late Miocene suites indicate that the post-Mesozoic lithospheric mantle, as represented by the latter, was entirely replaced by the former. The hot Pleistocene peridotites may thus represent new lithospheric additions associated with a post-Miocene lithospheric removal event or extension. High elevations, low sub-Moho seismic velocities, and the presence of fast velocity anomalies at 200 km depth may be manifestations of this event. If lithospheric removal occurred in the Mesozoic and Cenozoic, the observations presented here place constraints on the styles of lithospheric removal. In the Mesozoic, the lithospheric mantle was only partially removed, whereas in the Pliocene, the entire lithospheric mantle and probably the mafic lower crust were removed

Importance of emotional competence in designing an antidrug education curriculum for junior secondary school students in Hong Kong

Adolescent substance abuse is a serious problem in Hong Kong. Antidrug education campaigns should aim at enhancing students' understanding of the effects of illegal drugs to themselves. Moreover, life skill training is important in helping adolescents face life's challenges without attempting to do drugs. A major component of life skill training is the promotion of emotional competence. The present study outlines the importance of emotional competence and adolescent development. For an antidrug education campaign to be effective, adolescents should be able to identify their emotions and understand their own emotion regulation mechanism. Likewise, they should be made aware of the consequences of their emotions and emotion-driven behaviors. Finally, the use of an inspirational story with a strong message against substance abuse to trigger emotions is recommended for designing an antidrug education curriculum. All these components are integrated in the newly developed curriculum of the P.A.T.H.S. Project in Hong Kong. © 2011 Ben M. F. Law and Tak Yan Lee.published_or_final_versio

XML schema design and management for e-Government data interoperability

Open Access JournalThis journal issue entitled: ECEG 2009postprin

Potential Therapeutic Effects of Meditation for Treating Affective Dysregulation.

published_or_final_versio

UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells

The N-end rule pathway is a proteolytic system in which its recognition components (N-recognins) recognize destabilizing N-terminal residues of short-lived proteins as an essential element of specific degrons, called N-degrons. The RING E3 ligases UBR2 and UBR1 are major N-recognins that share size (200 kDa), conserved domains and substrate specificities to N-degrons. Despite the known function of the N-end rule pathway in degradation of cytosolic proteins, the major phenotype of UBR2-deficient male mice is infertility caused by arrest of spermatocytes at meiotic prophase I. UBR2-deficient spermatocytes are impaired in transcriptional silencing of sex chromosome-linked genes and ubiquitylation of histone H2A. In this study we show that the recruitment of UBR2 to meiotic chromosomes spatiotemporally correlates to the induction of chromatin-associated ubiquitylation, which is significantly impaired in UBR2-deficient spermatocytes. UBR2 functions as a scaffold E3 that promotes HR6B/UbcH2-dependent ubiquitylation of H2A and H2B but not H3 and H4, through a mechanism distinct from typical polyubiquitylation. The E3 activity of UBR2 in histone ubiquitylation is allosterically activated by dipeptides bearing destabilizing N-terminal residues. Insufficient monoubiquitylation and polyubiquitylation on UBR2-deficient meiotic chromosomes correlate to defects in double strand break (DSB) repair and other meiotic processes, resulting in pachytene arrest at stage IV and apoptosis. Some of these functions of UBR2 are observed in somatic cells, in which UBR2 is a chromatin-binding protein involved in chromatin-associated ubiquitylation upon DNA damage. UBR2-deficient somatic cells show an array of chromosomal abnormalities, including hyperproliferation, chromosome instability, and hypersensitivity to DNA damage-inducing reagents. UBR2-deficient mice enriched in C57 background die upon birth with defects in lung expansion and neural development. Thus, UBR2, known as the recognition component of a major cellular proteolytic system, is associated with chromatin and controls chromatin dynamics and gene expression in both germ cells and somatic cells. © 2012 Kwon et al

Missing Lead and High 3He/4He in Ancient Sulfides Associated with Continental Crust Formation

Major terrestrial reservoirs have Pb isotopes more radiogenic than the bulk silicate Earth. This requires a missing unradiogenic Pb reservoir, which has been argued to reside in the lower continental crust or dissolved in the core. Chalcophile element studies indicate that continent formation requires the formation of sulfide-bearing mafic cumulates in arcs. Because Pb, but not U, partitions into sulfides, we show that continent formation must have simultaneously generated time-integrated unradiogenic Pb reservoirs composed of sulfide-bearing cumulates, now recycled back into the mantle or stored deep in the continental lithosphere. The generation of such cumulates could also lead to coupled He-Pb isotopic systematics because 4He is also produced during U-Th-Pb decay. Here, we show that He may be soluble in sulfide melts, such that sulfide-bearing cumulates would be enriched in both Pb and He relative to U and Th, “freezing” in He and Pb isotopes of the ambient mantle at the time of sulfide formation. This implies that ancient sulfide-bearing cumulates would be characterized by unradiogenic Pb and He isotopes (high-3He/4He). These primitive signatures are usually attributed to primordial, undifferentiated mantle, but in this case, they are the very imprint of mantle differentiation via continent formation

The Effects of Chronic Pain Levels on Lower Extremity Energetics During Jump Landing/Cutting in Chronic Ankle Instability Patients

Up to 75% of patients with lateral ankle sprains develop chronic ankle instability (CAI). A majority of CAI patients report chronic pain and show altered jump landing/cutting patterns. Calculating joint energetics affected by chronic pain provides insight into understanding the effects of chronic pain levels on lower limbs in CAI patients. PURPOSE: To identify the effects of chronic pain levels on lower limb energetics during jump landing/cutting in CAI patients. METHODS: This study was a cross-sectional study. Fifteen CAI patients with high pain (High pain) (6males, 9females; age=22.1±2.1year; height=1.74±0.09m; mass=71.3±10.6kg, pain=66.9±9.4), matched 15 CAI patients with low pain (Low pain) (6males, 9females; age=22.3±2.1year; height=1.74±0.08m; mass=70.1±10.7kg, pain=89.3±2.6), and matched 15 healthy controls (Control) (6males, 9females; age=21.3±1.7year; height=1.73±0.08m; mass=70±10.3kg, pain=100±0). We followed the International Ankle Consortium and utilized the Foot and Ankle Outcome Scores for CAI and chronic pain levels. Ground reaction forces were collected during the jump landing/cutting, while joint power was defined by angular velocity and joint moment data. We calculated ankle, knee, and hip joint energy via the integration of negative (dissipation) or positive (generation) power curve areas. The loading phase was defined by the time from initial contact to 150 ms following, while the cutting phase extended from maximal knee flexion to 150 ms following. The Wilcoxon signed-rank test was used to assess joint energetics data. RESULTS: The high pain showed less energy dissipation and generation in the ankle during the loading and cutting phase than the low pain (p=.013 and p=.002) and control (p=.018 and p=.028). The high pain exhibited more energy generation in the hip during the cutting phase than the low pain (p=.038) and control (p=.013). CONCLUSION: The high pain showed lower energy dissipation and generation in the ankle during the loading and cutting phase than the low pain and control, possibly reflecting an effort to reduce the burden on the ankle joint. The high pain reported more energy generation in the hip during the cutting phase than the low pain and control, suggesting a proximal compensatory strategy. Therefore, chronic pain may impact motor outcomes

Internal distribution of Li and B in serpentinites from the Feather River Ophiolite, California based on laser ablation ICP-MS

International audienceLaser ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS) analyses of B and Li in serpentinized peridotites from the Feather River Ophiolite (California) indicates that B is enriched in serpentine minerals compared to the whole-rock and less altered olivine grains while Li in serpentine is depleted or comparable to whole-rock Li. The high B contents of serpentine minerals correlate with the relatively enriched whole-rock B contents. The low Li contents of serpentine minerals are consistent with the relatively low Li whole-rock contents and suggest that only small amounts of Li were added during serpentinization or that some Li was even leached out. A simple model of partial melting shows that Li/Yb increases with increasing melt depletion (and clinopyroxene depletion) in the peridotitic residue because Li is most compatible in olivine while Yb is most compatible in clinopyroxene. Thus, high Li/Yb ratios in peridotites by themselves do not indicate secondary enrichments in Li. However, Li/Yb and Yb contents of many of the Feather River Ophiolites plot above the melt depletion curve in Li/Yb versus Yb space, indicating that these serpentinites experienced subtle and preferential enrichments in Li during serpentinization. If serpentinized oceanic lithospheric mantle, as represented by the Feather River Ophiolite, is important in subduction recycling, then recycled mantle domains having a serpentinite protolith might be characterized by strong B enrichments but only small Li enrichments